Management Comment
"We believe CSF-1R antibodies may be complementary to immuno-oncology agents by selectively down regulating tumor promoting macrophages," said Dr. Michael L. Meyers, Chief Medical Officer of Syndax. "While entinostat inhibits regulatory T cells and myleoid-derived suppressor cells, UCB6352 down regulates tumor promoting macrophages, thereby diversifying our approach to reversing immunosuppression in the tumor microenvironment.  We believe there is significant opportunity for rapid and creative development of UCB6352 to treat a variety of indications.""The CSF1R program is further evidence of UCB's scientific expertise in monoclonal antibodies, aiming to provide disease modifying compounds for people living with severe diseases," said Ismail Kola, Executive Vice President and Chief Scientific Officer, UCB. "This novel program has promise for various oncology indications, and our aim was to find the best possible partner to further develop CSF1R's full potential. With their deep understanding of cancer disease mechanisms and clinical development expertise in oncology, we are excited to partner with Syndax."