This project has been flagged by a community member as inappropriate due to reason below.*

Expert Interview

Slingshot members are talking to an expert! The topic is:

Where does ZioPharma's "Sleeping Beauty" technology stand after the most recent Clinical Hold on the company's "very-rapidly manufactured CD19-specific T cells"?

Ticker(s): ZIOP

Who's the expert?

A leader in the CAR-T space with familiarity on the technological developments as well as unmet need. Experience in the process of bringing CAR-T products to approval through clinical trials would be ideal.

Interview Questions

Please describe your experience working in the CAR-T space. 

Added By: joe_mccann

Can you comment at a high level on your views of the "Sleeping Beauty" technology? How have those views evolved over time (If they have)?

Added By: joe_mccann

Can you walk me through the "Safety Switch" for the program that received the clinical hold on 6/18/18?

  • Am I correct in understanding it is referenced in this poster: Link
Is the safety swithc an Erbitux-triggered truncated EGFR (Her1t) technology, and if so what is your impression of that approach?

Added By: joe_mccann

According to management, the FDA's decision to place a clinical hold on Ziopharm's Phase I trial was primarily related to the CMC section of the application. While no specifics were given on our call, we do know that additional preclinical studies surrounding the treatment and the ability to manufacture these mIL15 CD19-specific CAR-T cells in <2 days were required.

  • Does this sound plausible to you for this stage of development?
  • Do you think the "Safety Switch" itself might also play a role in the FDA's decision?

Added By: joe_mccann

Can you summarize your thoughts on your excitement for this technology on a scale of 1-10 please?

Added By: joe_mccann

Are You Interested In These Questions?

Slingshot Insights Explained

Expert research benefits investors by giving them timely access to unbiased real world perspectives on highly specialized topics. Slingshot Insights' crowdfunded model makes this access available at a fraction of the cost of other expert networks.


*Slingshot Insights provides access to information, not investment advice. We work to support you and facilitate access to experts; however we are not responsible for monitoring calls for the disclosure of MNPI. You should obtain financial, legal and tax advice from your qualified and licensed advisers before deciding to invest in any security.