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Expert Interview
Preparing for MGL-3196 Data and Discussing the NASH Pipeline, with an additional focus on NGM282 and VK2809
Ticker(s): MDGL, NGM Bio, VKTXName: Dr Stephen Harrison - MD
Institution: University of Oxford (UK) and Pinnacle Clinical Research (US)
- Medical Director of Pinnacle Clinical Research.
- Leading authority on liver diseases.
- Peer-reviewer for over 20 medical journals and internationally known for studies in hepatitis C and non-alcoholic fatty liver disease with over 150 peer reviewed publications in these fields.
Please describe your background and familiarity with MGL-3196.
Added By: joe_mccannWhat are the links between liver fat and NASH? And what kind of percent fat reduction do you think is meaningful?
Added By: joe_mccannPlease give us your opinion on the three clinical candidates: MGL-3196, Viking 2809 and the NGM282.
Judging from what you saw in the 12 week data for MGL-3196, how that would correspond to 36 week data, and what are the major risks of those next 24 weeks?
What percentage of the patients with NASH are also diabetic, and do those patients have a worse prognosis?
Added By: c_adminWhat can biopsies tell you that we can't tell from MRI based methods, ultrasound and other markers like LiverMultiScan?
Added By: c_adminWhat do you think about FGF-19’s mechanism of action, as a potential oncogenic target?
Can you make a class comparison of CYMABAY or generally what you thought about their data at EASL and the class of PPAR?
Added By: c_adminWhat do you think about the thyroid hormone receptor beta as a target? What percent of the patients with hypothyroidism will have benefit?
Added By: c_adminAre You Interested In These Questions?
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