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Expert Interview

Slingshot members are talking to an expert! The topic is:

Analyzing the recent Phase 2 Etrasimod data and comparing it to Celgene's ozanimod in ulcerative colitis patients

Ticker(s): ARNA, CELG

Who's the expert?

A gastroenterologist who has significant experience treating UC patients and is familiar with the OASIS data.

Interview Questions

Please describe your clinical practice and how many UC patients you treat.

Added By: joe_mccann

How are you currently treating UC patients? Do you currently prescribe 5-aminosalicylic acid drugs such as sulfasalazine, mesalazine, or corticosteroids, and how well managed are your patients?

  • Have you encountered severe adverse effects cases with the 5-ASA drugs, such as myelosuppression, pancreatitis, liver problems, myocarditis; as there have been reports of such risk when using Mesalazine.

Added By: joe_mccann

Adalimumab (Humira) has also been approved in the recent years for treatment in ulcerative colitis. What has been your experience with it? Having been approved for many other indications, has it seen broad use in your field?

Added By: joe_mccann

What are your initial impressions of the P2 OASIS data released on 3/20? In the recent Phase 2 data release, the 1 mg group saw a 0.43 point improvement, and the 2 mg group, 0.99 in stool frequency, rectal bleeding and findings on endoscopy.

  • Are those numbers relevant enough in your opinion to vouch for the drug's efficiency? How does it compare to the drugs in your first line of therapy
  • Endoscopic improvement was also at 41.8% for the 2 mg group vs. 17.8% in the placebo group. What are your thoughts on this improvement?

Added By: joe_mccann

Does etrasimod have the potential to be used in stopping progression towards intraepithelial neoplasia or colitis-associated cancer, given those findings? Or are there better results to be found with other medications, in your opinion?

Added By: c_admin

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