This project has been flagged by a community member as inappropriate due to reason below.*

Expert Interview

Slingshot members are talking to an expert! The topic is:

Analyzing Marinus’ Ganaxolone in treating Postpartum Depression, after its Phase 2 Magnolia and Amaryllis trials data

Ticker(s): MRNS, SAGE

Who's the expert?

An obstetrician or psychiatrist with experience treating women with postpartum depression with allopregnanolone who is familiar with the literature to date for ganaxolone.

Interview Questions

Please tell us about your clinical practice and more specifically, about your experience with PPD patients. How many patients with postpartum depression do you currently manage?

Added By: c_admin

What is the first-line treatment for PPD? How effective is this therapy?

Added By: c_admin

Ganaxolone has also been studied in trials for Migraine, Neuropathic pain and Partial epilepsies, trials which have been terminated. Do you see any similarities between those trials and the Magnolia and Amaryllis trials in PPD?

Added By: c_admin

How effective are GABA A receptor agonists in treating PPD?

Added By: c_admin

Ganaxolone is being used as both IV and oral regimens in the two Phase 2 trials. Do you see the IV formulation as having a significant advantage as an acute treatment? How likely would you be to consider IV therapy for your patients suffering from PPD?

Added By: c_admin

What is your feedback regarding the use of allopregnanolone, which is quite identical in composition to ganaxolone, except for the fact that ganaxolone does not convert back to progesterone.

  • The company cites that ganaxolone has no hormonal side effects. Has this been a serious issue with allopregnanolone? 
  • Is there a need for ganaxolone in this space? How often is allopregnanolone currently being used in PPD now?

Added By: c_admin

Sage’s brexanolone recently achieved the primary endpoints in both of its Phase 3 studies in PPD. What are your thoughts on that data?

  • If approved, how likely would you be to switch patients to brexanolone
  • Can ganaxolone compete against it?

Added By: c_admin

Are You Interested In These Questions?

Slingshot Insights Explained

Expert research benefits investors by giving them timely access to unbiased real world perspectives on highly specialized topics. Slingshot Insights' crowdfunded model makes this access available at a fraction of the cost of other expert networks.


*Slingshot Insights provides access to information, not investment advice. We work to support you and facilitate access to experts; however we are not responsible for monitoring calls for the disclosure of MNPI. You should obtain financial, legal and tax advice from your qualified and licensed advisers before deciding to invest in any security.