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Expert Interview

Slingshot members are talking to an expert! The topic is:

Preparing for the upcoming PALISADE Phase 3 trial of AR101 anticipated in February 2018

Ticker(s): AIMT, DBVT

Who's the expert?

Name: Dr Jonathan Spergel - MD

Institution: Children's Hospital of Philadelphia

  • Chief of the Allergy section at CHOP and professor of Pediatrics at The Perelman School of Medicine at UPENN.
  • Treats 30 peanut allergic patients a month and familiar with the AR101 data.
  • Has published over 170 peer reviewed articles and has received funding from NIH, FARE and numerous foundations.

Interview Questions
Q1.

Please describe your clinical background and how you currently manage your peanut allergy patients.

Added By: joe_mccann
Q2.

What are your expectations for AR101's Phase 3 trial?

Added By: joe_mccann
Q3.

What % of your patients would you anticipate wanting to use AR101 if approved?

Added By: joe_mccann
Q4.

Please speak about the design of the PALISADE trial. Based on Phase 2 data, do you have any concerns? There were 6 patients in the AR-101 group that withdrew as “non-responders”. Does this concern you?
What risks do you see regarding the meeting of the primary endpoints? Are you comfortable with the amount of peanut protein tolerance Is necessary to be deemed a success?

Added By: eesmer
Q5.

AnaptysBio, Inc will announce Phase 2 data for their IL-33 inhibitor ANB020 very shortly.  NCT02920021.  This is a *one-dose* treatment, though the trial is for adults, not children.  But, if successful, won't a one-dose treatment make the year-long therapies of AR101 or Viaskin seem very undesirable?  Do you have any thoughts on this ANB020 drug?  

Added By: philk
Q6.

What amount of efficacy and safety from the PALISADE trial would you consider "success" - meaning, make it a preferred option for patients over Viaskin?

Added By: philk

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