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Expert Interview

Slingshot members are talking to an expert! The topic is:

A 4th View - Discussing the market potential of TYMLOS (Abaloparatide) after approval and positive ACTIVExtend results in osteoporosis.

Ticker(s): RDUS, MRK, AMGN, LLY

Who's the expert?

Name: Dr Nancy Lane - MD

Institution: University of California

  • Director for the Center for Musculoskeletal Health at UC Davis, Endowed Professor of Medicine, Rheumatology, and Aging Research.
  • Research focuses on osteoporosis and osteoarthritis.  Her translational research team has been instrumental in defining the role of glucocorticoids in bone fragility including their effects on cell stress and vulnerable cell populations including osteocytes.
  • Principal Investigator of the NIH funded Program on Sex Differences in Musculoskeletal Diseases Across the Lifespan.

Interview Questions

Please describe your clinical practice and how many postmenopausal women you treat with osteoporosis at high risk for fracture.

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Which of your patients are you most likely to have try TYMLOS?

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How do you view the side effect profile of TYMLOS? Does the black box warning on osteosarcoma concern you?

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Please explain the mode of action and can you compare the benefit vs other products including
1. Decrease in fracture risk at the femoral neck and lumbar spine
2. Increase in BMD vs competitors 

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FORTEO and abaloparatide-SC are daily injections, whereas romosozumab is injected once a month. How will this affect the popularity of each drug?  Do these differences suggest romosozumab fits a niche market within osteoporosis?

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How does the side effect profile of TYMLOS compare to Forteo and Prolia in your opinion?

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