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Expert Interview

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Another Opinion - Discussing the market potential of TYMLOS (Abaloparatide) after approval and positive ACTIVExtend results in osteoporosis.

Ticker(s): RDUS, MRK, AMGN, LLY

Who's the expert?

Name: Dr Julia Charles - MD, PhD

Institution: Brigham and Women's Hospital

  • Rheumatologist (Clinician scientist) at BWH who runs a Fracture Liaison Clinic in conjunction with the Department of Orthopedics at BWH Faulkner Hospital.
  • Treats ~100 women currently with osteoporosis.
  • Research interest in osteoclast-osteoblast interactions, inflammatory bone loss and the role of the gut microbiome in modulating host bone turnover. 

Interview Questions

Please describe your clinical practice and how many postmenopausal women you treat with osteoporosis at high risk for fracture.

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Which of your patients are you most likely to have try TYMLOS?

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How do you view the side effect profile of TYMLOS? Does the black box warning on osteosarcoma concern you?

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Please explain the mode of action and can you compare the benefit vs other products including
1. Decrease in fracture risk at the femoral neck and lumbar spine
2. Increase in BMD vs competitors 

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FORTEO and abaloparatide-SC are daily injections, whereas romosozumab is injected once a month. How will this affect the popularity of each drug?  Do these differences suggest romosozumab fits a niche market within osteoporosis?

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How does the side effect profile of TYMLOS compare to Forteo and Prolia in your opinion?

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