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Expert Interview

Slingshot members are talking to an expert! The topic is:

Understanding Spark's LUXTURNA potential in RPE65-mediated IRD blindness currently under review at the FDA

Ticker(s): ONCE

Who's the expert?

An Ophthalmologist who treats pediatric patients with IRD. Ideally this expert would have participated in a developmental trial for LUXTURNA.

Interview Questions
Q1.

Please describe your  clinical practice. How many patients do you treat with IRD, how are they managed currently?

Added By: joe_mccann
Q2.

Can we walk through the primary endpoint of bilateral multi-luminance mobility testing (MLMT) from the Lancet study? How well established is this endpoint and how consistent is the decline among untreated patients? 

Added By: joe_mccann
Q3.

LUXTURNA showed a marked difference compared to control participants across the first two secondary endpoints: full-field light sensitivity threshold (FST) testing (p<0.001) and the mobility test change score for the first injected eye (p=0.001). A third secondary endpoint, the change in visual acuity (VA) averaged over both eyes, was not statistically significant between intervention and control participants (p=0.17).

Let's discuss the 3 endpoints and how concerning it is the drug didn't hit a statistically significant benefit on the VA endpoint.

Added By: joe_mccann

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Reason

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