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Expert Interview

Slingshot members are talking to an expert! The topic is:

Investigating Loxo’s larotrectinib in treating TRK cancers with upcoming data in Q4

Ticker(s): LOXO, EXEL, RXDX, NVS

Who's the expert?

An oncologist with clinical experience in treating TRK fusion cancers with at least one of the available multikinase/TRK inhibitors.

Interview Questions

Please describe your clinical experience and the patient demographics who suffer from TRK fusion cancers.

Added By: c_admin

Out of all the 55 patients enrolled in LOXO’s 101 trials, 22% had either stagnated or progression in the disease, and in 76% of the patients tumor reduction in size was observed. 12% of the patients had complete response rate. 6 patients responded to larotrectinib but subsequently progressed. What's your opinion of this data and how likely would you be to make a switch from other treatment options?

Added By: c_admin

Have you used Cabozantinib (Cabometyx) in your clinical practice, since its FDA approval in April 2016?  What is the first line of treatment, when you need to use a TRK inhibitor drug? Have you been using midostaurin, crizotinib, entrectinib or regorafenib, and what has been your experience with them?

Added By: c_admin

The FDA’s Pediatric Subcommittee granted its support for larotrectinib after observing its effects in a phase I trial enrolling patients 1 to 21 years of age. Are there bigger safety concerns regarding risk and adverse effects in this patient population?

Added By: c_admin

On a scale from 1-10, with 10 being very excited, how would you rate your level of excitement for this drug if approved?

Added By: c_admin

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