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Expert Interview

Slingshot members are talking to an expert! The topic is:

A look at the Phase 1b/2 DURGA-1 study results presented at ASH evaluating AZD0120, AstraZeneca’s dual BCMA/CD19 CAR T-cell therapy for relapsed/refractory multiple myeloma

Ticker(s): AZN

Who's the expert?

Institution: Washington University St. Louis

  • Professor Department of Medicine Oncology Division Bone Marrow Transplantation & Leukemia at WUSTL
  • Currently treats ~300 patients with multiple myeloma, 25 patients with AML, 10 patients with CMML, and ~15 patients per month with AL Amyloidosis.
  • Clinical research focus on strategies to improve the outcome of patients with multiple myeloma, acute myeloid leukemia, and myelodysplastic syndromes.

Interview Questions
Q1.

From your perspective, what differentiates AZD0120’s dual BCMA/CD19 CAR T-cell construct from currently approved single-target BCMA CAR T therapies in relapsed/refractory multiple myeloma?

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Q2.

How do you interpret the efficacy signals reported in the Phase 1b/2 DURGA-1 study, particularly in heavily pretreated or high-risk patient populations?

Added By: sara_admin
Q3.

Do you see dual-target CAR T approaches like AZD0120 as a meaningful strategy to address antigen escape and durability of response in multiple myeloma?

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