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Expert Interview

Slingshot members are talking to an expert! The topic is:

Examining the Phase 3 STELLAR-303 Results for Zanzalintinib plus Atezolizumab in Metastatic Colorectal Cancer

Ticker(s): EXEL

Who's the expert?

A gastrointestinal medical oncologist specializing in metastatic colorectal cancer, experienced with later-line therapies and immunotherapy-TKI combinations. The expert should be familiar with VEGF- and MET-pathway biology, subgroup differences such as liver metastasis status, and practical considerations when sequencing regorafenib and other target-based regimens. Experience interpreting survival-endpoint–driven Phase 3 data and understanding toxicity trade-offs for kinase inhibitor–immunotherapy combinations is preferred.

Interview Goal
The interview aims to analyse the detailed Phase 3 STELLAR-303 results evaluating zanzalintinib in combination with atezolizumab versus regorafenib in previously treated metastatic colorectal cancer. The discussion will explore the overall survival benefit, progression-free survival trends, subgroup consistency, safety profile, and the implications of these data for patients without liver metastases. It will also consider how this combination could alter treatment strategies in non-MSI-high metastatic CRC and inform Exelixis’ planned NDA submission.

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Reason

*Slingshot Insights provides access to information, not investment advice. We work to support you and facilitate access to experts; however we are not responsible for monitoring calls for the disclosure of MNPI. You should obtain financial, legal and tax advice from your qualified and licensed advisers before deciding to invest in any security.