Expert Interview
A look at Protagonist and Takeda's new Phase 3 VERIFY study data of rusfertide, a hepcidin mimetic in development for polycythemia vera.
Ticker(s): PTGX, TAKInstitution: Richard T. Silver Myeloproliferative Neoplasm (MPN) Center at Cornell
Hematologist and Oncologist specializing in the care of patients with myeloproliferative neoplasms (MPNs) and related blood disorders
Treats nearly 100 polycythemia vera (PV) patients a year
Primary research focus is on developing curative therapies that target malignant stem cells in MPNs through translational studies that bridge laboratory discoveries with patient care
Given rusfertide’s mechanism as a hepcidin mimetic, how do you see its role differing from current cytoreductive agents like hydroxyurea or ruxolitinib? Are there specific PV patient subtypes (e.g., low-risk, phlebotomy-dependent) who might benefit most from rusfertide?
Added By: sara_adminHow do the VERIFY Phase 3 results for rusfertide compare with your expectations, particularly in terms of hematocrit control and phlebotomy independence? Do you believe this data positions rusfertide as a viable frontline or adjunctive therapy in PV?
Added By: sara_adminWhat are your thoughts on the long-term tolerability and safety profile of rusfertide, particularly regarding injection site reactions or iron metabolism effects? Would this impact patient adherence or influence how you sequence therapy?
Added By: sara_adminAre You Interested In These Questions?
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