Expert Interview
Discussing the recent FDA approval of Amgen's LUMAKRAS® (sotorasib) in combination with Vectibix® (panitumumab) for the treatment of adult patients with KRAS G12C-mutated metastatic colorectal cancer.
Ticker(s): AMGNInstitution: CIMCA
- Medical Oncologist and Director of the Centro de Investigación y Manejo del Cáncer (CIMCA) in San José, Costa Rica.
- Treats 5 new patients every month with mCRC, with 2.5% of them being KRAS G12C-mutated mCRC.
- Research interest in thoracic oncology and is the lead investigator for several international clinical trials at CIMCA.
Can you discuss your professional background, clinical practice, and the prevalence of KRAS G12C mutations in your mCRC patients?
How has the approval of Lumakras + Vectibix changed the treatment landscape compared to previous standards and the approval of Adagrasib + Cetuximab?
How do the efficacy and safety profiles of Lumakras + Vectibix compare to Krazati-based regimens, and what role does toxicity play in treatment choice?
What barriers exist to accessing Lumakras, and how do they compare to challenges with Krazati? What percentage of second-line patients could realistically receive Lumakras + Vectibix given these constraints?
Added By: slingshot_insightsWhat are your thoughts on Amgen’s CodeBreaK 301 trial using Lumakras + Panitumumab + Folfiri, and why was Folfiri chosen over Folfox? Should future trials explore non-G12C KRAS mutations?
Added By: slingshot_insightsAre You Interested In These Questions?
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