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Expert Interview

Slingshot members are talking to an expert! The topic is:

Evaluating BridgeBio's (BBIO) Phase 3 ATTRibute-CM Trial Results for Attruby (Acoramidis) in ATTR-CM Patients

Ticker(s): BBIO

Who's the expert?

A cardiologist specializing in amyloidosis and heart failure management, with expertise in evaluating novel therapies and understanding their role in reducing cardiovascular morbidity and mortality. The expert should have insights into the challenges of treating ATTR-CM and familiarity with TTR stabilization mechanisms.

Interview Questions
Q1.

Attruby achieves ≥90% TTR stabilization, the highest reported to date. How does this level of stabilization translate into clinical benefits for ATTR-CM patients compared to existing treatments?

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Q2.

The ATTRibute-CM trial demonstrated a separation in cardiovascular outcomes as early as three months. What does this rapid onset of benefit suggest about the mechanism of action and potential real-world impact of Attruby?

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Q3.

Attruby reduced composite cardiovascular mortality and hospitalization by 42% at Month 30. How transformative are these findings for patients with ATTR-CM, particularly those with limited options?

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Q4.

Improvements in 6-minute walk distance, Kansas City Cardiomyopathy Questionnaire scores, and NT-proBNP were observed. How do these measures reflect on the overall efficacy and quality-of-life improvements for patients?

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Q5.

Attruby showed a mild safety profile, with common side effects such as diarrhea resolving without discontinuation. How does this profile position it as a first-line treatment for ATTR-CM?

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Q6.

In a crowded therapeutic space for ATTR-CM, how does Attruby’s mechanism of mimicking the T119M rescue mutation differentiate it from other stabilizers or emerging therapies?

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