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Expert Interview

Slingshot members are talking to an expert! The topic is:

Investigating the phase III results from the ANCHOR clinical trials on depemokimab in chronic rhinosinusitis with nasal polyps.

Ticker(s): GSK

Who's the expert?

Institution: Scripps Clinic

  • Allergist/Immunologist & Director, Aspirin Exacerbated Respiratory Disease Clinic,Division of Allergy, Asthma and Immunology at the Scripps Clinic.
  • Currently manages 35 patients with systemic mastocytosis.
  • Focus is on Aspirin exacerbated respiratory disease (AERD), mastocytosis, and mast cell activation syndromes; conducts research on aspirin exacerbated respiratory disease, a topic on which he has authored multiple publications and ongoing research protocols.

Interview Questions
Q1.

What are the current treatments available for chronic rhinosinusitis with nasal polyps, and how do you determine the progression from first-line to third-line treatment options?

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Q2.

How do you manage patients who do not respond well to a biologic like Dupixent, and when do you consider switching biologics or opting for surgery?

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Q3.

What factors influence the choice of biologics, and how do you address patient concerns about injection frequency, cost, or needle anxiety?

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Q4.

How does depemokimab compare to other biologics like Dupixent or omalizumab in terms of mechanism, efficacy, and the six-month dosing schedule?

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Q5.

What are the key safety concerns, side effects, and insurance coverage challenges associated with biologics, including new treatments like depemokimab?

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