Expert Interview
Discussing the potential of EO-3021, a Claudin 18.2 ADC), and the Phase I trial in gastric (GC), gastroesophageal junction (GEJ), and pancreatic cancers.
Ticker(s): ELEV, ALPMYInstitution: Duke University
- Gastrointestinal Oncologist and Professor of Medicine in the Department of Surgery at Duke University
- Manages 30+ patients with pancreatic cancer
- Research interest in immune therapies for treating GI cancers
How do you currently treat gastric cancer?
Added By: sara_adminHow does EO-3021 compare to Astellas Claudin 18.2 candidate Zolbetuximab?
Added By: sara_adminWhat are your impressions of the data shown from the anti Claudin 18.2 therapies?
Added By: sara_adminWhat are the current treatment options for advanced gastric (GC), gastroesophageal junction (GEJ), and pancreatic cancers, and how are molecular markers like Claudin 18.2, PD-L1, HER2, and MSI used to guide therapy selection?
Added By: slingshot_insightsHow does the expression of Claudin 18.2 correlate with other biomarkers, and how is treatment determined when patients express multiple markers such as PD-L1 and Claudin 18.2?
Added By: slingshot_insightsWhat are your thoughts on the efficacy and safety of EO-3021 compared to other Claudin 18.2-targeting therapies, including zolbetuximab and ADCs like CMG901?
Added By: slingshot_insightsHow does the site-specific conjugation and lower MMAE toxicity of EO-3021 influence its tolerability and potential advantages in treating high Claudin 18.2-expressing patients?
Added By: slingshot_insightsWith zolbetuximab approved for earlier-line treatment, how will EO-3021 position itself in later lines of therapy, and what are the challenges in demonstrating efficacy in a heavily pre-treated population?
Added By: slingshot_insightsAre You Interested In These Questions?
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