Expert Interview
A third Look: Discussing FcRn and CD19 as a target in primary immune thrombocytopenia (ITP)
Ticker(s): AMGN, ARGX, ELYMInstitution: Lund University
- Professor of Transfusion Medicine at Lund
- His research is aimed at understanding the cellular immune mechanisms responsible for the generation of IgG antibodies that recognize platelet antigens.
- Currently the Scientific Secretary of the International Society of Blood Transfusion and sits on the editorial board of the journals Blood, Haematologica and Transfusion.
Roughly how many patients with ITP do you currently manage?
Added By: wilson_adminWhat are your views on Rituximab's efficacy in treating ITP, particularly regarding its effectiveness in younger women and the challenges of long-term remission?
How do you evaluate the mixed data on FcRn-targeting drugs, specifically the IV and Sub-Q formulations, in managing ITP, and what are the potential implications of these results?
What insights can you provide on the early data for CD38 and CD19 as targets in ITP, particularly regarding their mechanisms of action and the potential for durable responses in different patient populations?
How significant is the role of CD19, especially in the context of CAR T-cell therapy for refractory ITP, and what are the prospects and challenges of using monoclonal or bispecific antibodies targeting CD19?
What are your thoughts on alternative targets like BAFF, APRIL, and other emerging therapies in ITP, and how do they compare with existing treatments like Tpo agonists and anti-CD20 therapies?
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