Expert Interview
A second look: Discussing the recent phase 2 data of barzolvolimab in two of the most common forms of CIndU - Cold Urticaria and symptomatic dermographism
Ticker(s): CLDXInstitution: Penn State University
- Professor, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine at Penn State University.
- Currently manages over 120 patients with hereditary angioedema and has written guidelines for international management of urticaria, hereditary angioedema and rhinitis with more than 300 publications.
- Clinical research and clinical care focuses include asthma, COPD, alpha-1-antitrypsin deficiency, urticaria, hereditary angioedema, immunodeficiency, vaccine response and other respiratory, allergic and immunologic diseases.
Roughly how many patients with cold urticaria do you manage annually?
Added By: wilson_adminOn a scale from 1-10 (10 being extremely excited) where would you rate your level of excitement for barzolvolimab?
Added By: wilson_adminCan you provide an overview of your clinical practice and research interests, specifically regarding urticaria?
Added By: wilson_adminHow common are induced urticaria cases in your practice, and how do they typically present in comparison to spontaneous urticaria?
What are the etiological differences between chronic spontaneous urticaria and induced urticaria?
What theories do you have about the triggers of chronic urticaria, and how do these impact treatment approaches?
What percentage of your patients with induced urticaria show insufficient response to antihistamines and XOLAIR?
How do you perceive the potential of barzolvolimab compared to omalizumab, especially considering safety profiles and side effects like hair color changes and neutropenia?
What are your thoughts on the efficacy and clinical testing methods used for barzolvolimab, and how do these compare to standard practice?
How do you foresee BTK inhibitors, particularly remibrutinib from Novartis, fitting into the treatment landscape for chronic spontaneous urticaria?
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