Expert Interview
Discussing the recent MASH/NASH data presented at the 2024 EASL Congress with a focus on Madrigal's Rezdiffra (resmetirom) and Lilly's tirzepatide
Ticker(s): MDGL, LLYInstitution: Rush University Medical Center
- Professor of Internal Medicine, Chair of Hepatology, & Associate Director of Solid Organ Transplantation,at Rush University Medical Center.
- Research interests focus on viral hepatitis – from both a drug development and a clinical perspective - liver transplantation, and complications of chronic liver disease.
- Author of the AASLD/IDSA hepatitis C guidance document; Co-chair of the National ALF Medical Advisory Committee and is currently a member of the steering committee for the hepatitis C special interest group for the AASLD.
The MAESTRO-NASH study utilized an AI-based analysis to assess biopsy data. Can you explain how this AI-driven approach enhances our understanding of Rezdiffra's impact on fibrosis and its predictive value for progression to decompensated cirrhosis?
Added By: sara_adminNoninvasive test data over three years showed that 91% of patients achieved improvement or stabilization of liver stiffness with Rezdiffra. How does this durability compare to other treatments for NASH, and what implications does it have for long-term patient management?
Added By: sara_adminRezdiffra has shown improvements in health-related quality of life for patients with NASH. Can you discuss the importance of these findings, particularly in the domains of patient worry, health distress, and stigma, and how they influence overall treatment outcomes?
Added By: sara_adminThe MAESTRO-NASH study included an analysis of patients with metabolic dysfunction and alcohol-associated liver disease (MetALD). What are the key findings from this subgroup, and how do they compare to the overall NASH population in terms of fibrosis improvement and steatohepatitis resolution?
Rezdiffra achieved significant improvements in fibrosis and NASH resolution at week 52. What mechanisms might explain Rezdiffra's ability to improve fibrosis, and how does this compare to other therapeutic approaches currently under investigation?
Added By: sara_adminThe study identified 30 fibrotic features predictive of progression to cirrhosis using the SteatoSITE database. How critical is the integration of such biomarkers in developing personalized treatment plans for NASH patients?
Added By: sara_adminPatients in the MAESTRO-NASH trial continue on therapy for up to 54 months. What are the expectations for long-term efficacy and safety from this extended follow-up, and how might these results impact the future approval and use of Rezdiffra?
Added By: sara_adminGiven the promising results from the MAESTRO-NASH Phase 3 study, what steps are necessary to integrate Rezdiffra into standard clinical practice for treating NASH? What challenges might clinicians face in adopting this new treatment?
Added By: sara_adminAre You Interested In These Questions?
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