Expert Interview
A second look: Discussing current treatment options for CLL and the potential of Nurix Therapeutics' NX-5948, a BTK degrader
Ticker(s): NRIXInstitution: UCI Irvine
- Hematologist and Oncologist, and Associate Professor — Division of Hematology-Oncology, Department of Medicine, UCI School of Medicine.
- Currently manages 200 patients with CLL annually and is familiar with Nurix Therapeutics' BTK degraders NX-2127 and NX-5948.
- Specializes in chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL), which has been her research focus for more than a decade as a principal investigator of numerous clinical trials of novel agents that have improved the care of these patients.
Can you elaborate on the clinical implications of the 69.2% objective response rate observed in the heavily pretreated patient population in the NX-5948 trial?
How significant are the rapid and deepening clinical responses in CLL patients treated with NX-5948, especially considering the patients' history of resistance to BTK inhibitors?
Added By: slingshot_insightsWhat impact does the ability of NX-5948 to achieve responses as early as the first scan (8 weeks) have on the overall treatment landscape for relapsed or refractory CLL?
NX-5948 showed efficacy in a patient cohort with a high prevalence of BTK inhibitor resistance mutations. How does this influence the potential role of NX-5948 in the treatment of CLL?
The Phase 1a/b trial included patients with various poor prognostic features, such as TP53 mutations and CNS involvement. What does the response of these subgroups suggest about the robustness of NX-5948?
Added By: slingshot_insightsWith Nurix planning to advance NX-5948 into pivotal trials in 2025, what key data from the ongoing study will be critical for the next stage of development?
Added By: slingshot_insightsHow does the safety profile of NX-5948, which was well tolerated across all doses with common adverse events being manageable, compare to existing treatments for relapsed or refractory CLL?
Added By: slingshot_insightsBeyond CLL, what potential does NX-5948 have for treating other B-cell malignancies, and what are Nurix's plans for exploring these additional applications?
Added By: slingshot_insightsAre You Interested In These Questions?
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