Expert Interview
Navigating New Frontiers in Follicular Lymphoma: An In-depth Look at Bristol Myers Squibb’s Breyanzi (lisocabtagene maraleucel)
Ticker(s): BMYInstitution: Mayo Clinic
- Professor of Medicine in the Division of Hematology/Oncology at the Mayo Clinic Florida
- Manages 50 patients with Waldenström's macroglobulinemia and can speak to the data available for iopofosine and the CLOVER-WaM study.
- Clinical focus includes the treatment of plasma cell disorders, multiple myeloma (MM), Waldenström's macroglobulinemia, and chronic lymphocytic leukemia (CLL).
Could you describe how Breyanzi's mechanism of action, targeting CD19 with a 4-1BB costimulatory domain, is potentially transformative for patients with relapsed or refractory follicular lymphoma?
Added By: catalin_adminIn the TRANSCEND FL study, Breyanzi achieved high rates of complete response in patients. What does this signify for the treatment landscape of follicular lymphoma, especially considering these were high-risk, second-line patients?
Added By: catalin_adminHow does the efficacy and safety profile of Breyanzi compare with traditional therapies or other CAR T cell therapies currently in use for follicular lymphoma?
Added By: catalin_adminWith the upcoming PDUFA decision on May 23 for Breyanzi in FL, what are the potential implications for patient care should this therapy receive approval?
Added By: catalin_adminBreyanzi's trials reported manageable safety profiles but noted occurrences of cytokine release syndrome and neurotoxicity. How should healthcare providers prepare to manage these side effects effectively?
Added By: catalin_adminHow would oncologists determine the best candidates for Breyanzi treatment, and what are the challenges in ensuring broader access to this therapy for eligible patients?
Added By: catalin_adminHow do you sequence BsAb and CAR-T for FL patients?
Added By: wzhu0611Are You Interested In These Questions?
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