Expert Interview
A Fresh Look at Arrowhead Pharmaceuticals' Plozasiran in Treating Hypertriglyceridemia
Ticker(s): ARWRInstitution: Baylor University College of Medicine
- Interventional Cardiologist, Associate Professor, and Chief of Cardiology at Baylor College of Medicine.
- Treats ~75 patients with pulmonary arterial hypertension.
- Studies the molecular mechanisms of cardiovascular development with a focus on the intrinsic signaling that trigger cardiac regeneration early in life, molecular events that regulate developmental decisions instructing cardiac progenitor cells to adopt a specific cell fate, and delivery approaches of cardiovascular progenitors into an injured heart.
- Recently identified several novel surface markers that can highly enrich for early cardiovascular progenitors and his studies have established the basis for future PSC-based cardiac therapy.
Describe your background and practice setting
What is your opinion on the safety profile and tolerability of Plozasiran based on the trial data?
How do you interpret the reductions in triglycerides but correlated increases in HDL-cholesterol?
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