How many patients with Narcolepsy are under your care?

How many patients with Narcolepsy do you have on an Oxybate drug (e.g., Xyrem, Xywav, Lumryz) right now?

How many NARCOLEPSY patients do you currently have on the following treatments (please do not count IH patients in the figures below):

• Xyrem branded:
• Xyrem generic:
• Xywav:
• Lumryz:

Of the [X] narcolepsy patients you currently have on Lumryz, how many of them:

• Are switches from Xyrem/Xywav?
• Are new Oxybate starts?

What percentage (%) of patients who initially enroll in the RYRUP program do you expect to ultimately get insurance coverage for Lumryz and start taking the drug?

Please describe the current level of patient awareness of Lumryz and its potential benefits and how the level of awareness compares with 6 months ago?  

Please describe patient satisfaction with Lumryz (after patients have initiated treatment and completed titration) compared to Xyrem or Xywav?

Is patient uptake of Lumryz going better or worse than you would have expected when it first launched about a year ago?

Is the ease of prescribing and insurance acceptance of Lumryz going better or worse than you would have expected when Lumryz first launched about a year ago?

Of the existing patients you currently have on Xyrem or Xywav, how many do you expect to switch to (and stay on after switching) Lumryz over the next 12 months?

Of the patients that you had on Xyrem and Xywav last year prior to the Lumryz launch, what % of those patients do you think will end up staying on Xyrem/Xywav (either because they never try a switch to Lumryz or end up preferring Xyrem/Xywav after an attempted switch)?

What % of the patients who attempt a switch from Xyrem or Xywav to LUMRYZ end up staying with Lumryz 6 months out vs. wanting to switch back?

How many patients do you expect to have on Lumryz at the following points in time (please factor new-to-oxybate starts, switches from Xyrem or Xywav, and drops):

• 3 months from now:
• 6 months from now:
• 1 year from now:
• 2 years from now:

Looking ahead to new Oxybate starts in the next year, what percentage (%) do you expect to end up on Lumryz?

Do you think having a 1x nightly dosing option with Lumryz will significantly increase the overall use of oxybate treatments in your practice?

• Yes
• No

Why or why not?

What percent (%) do you expect the overall oxybate population in your practice to grow, if at all, at the following timepoints:

• 1 year
• 3 years
• 5 years

What are the biggest issues (if any) that are holding back adoption of or persistence on Lumryz (i.e. taste of drug, insurance coverage, awareness, reluctance to switch from an existing routine that works, etc)?

To what extent have you attempted to and/or succeeded with prescribing Lumryz on an off-label basis for Pediatric use or IH?

On a scale 1-10 (where 1 is low and 10 is high) how excited are you about the potential benefits of Lumryz for your patients with narcolepsy?