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Expert Interview

Slingshot members are talking to an expert! The topic is:

Advancing Lyme Disease Prevention: A Comprehensive Analysis of TP-05 and VLA15 in Prophylactic Strategies

Ticker(s): TARS, VALN

Who's the expert?

Institution: Penn Presbyterian Medical Center

  • Associate Professor of Clinical Medicine (Infectious Diseases) and Medical Director, Infectious Diseases Transition Service at Penn Presbyterian Medical Center.
  • Currently manages about 2-4 patients with Lyme Disease per week. 
  • Clinical expertise in HIV and AIDS, Lyme Disease, Osteomyelitis, Outpatient Antimicrobial Treatment (OPAT), STD's, Travel Medicine, and  Tuberculosis (TB).

Interview Questions
Q1.

Can you discuss the significance of TP-05's tick mortality rates observed in the Carpo trial and its potential impact on Lyme disease prevention?

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Q2.

How do the mechanisms of TP-05 and VLA15 differ in preventing Lyme disease, and what are the implications of these differences for their use in prophylaxis?

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Q3.

Based on the trial data, how do the safety profiles of TP-05 and VLA15 compare, and what does this mean for their potential widespread use?

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Q4.

How does the efficacy of VLA15, as indicated by the seroconversion rates and GMTs post-booster dose, vary across different age groups?

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Q5.

Could combining TP-05's tick-killing action with VLA15's immunogenic response offer a more comprehensive approach to Lyme disease prevention

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Q6.

What can be inferred about the long-term protection prospects against Lyme disease with the use of TP-05 and VLA15, either separately or in combination?

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Q7.

How do TP-05 and VLA15 compare with existing Lyme disease prevention strategies, particularly in terms of efficacy and ease of use?

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Q8.

What are the anticipated next steps in the clinical development of TP-05 and VLA15, and how might these developments alter the landscape of Lyme disease prevention?

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Q9.

How concerning is the FDA warning about drugs in this class causing tremors in dogs and cats:
“Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats”

https://www.fda.gov/animal-veterinary/animal-health-literacy/fact-sheet-pet-owners-and-veterinarians-about-potential-adverse-events-associated-isoxazoline-flea


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