Expert Interview
Wet AMD Treatment Landscape: In-Depth Analysis of EyePoint's EYP-1901 and 4D Molecular's 4D-150 from their recent Clinical Trials
Ticker(s): EYPT, FDMTInstitution: Wills Eye Hospital
- Assistant Professor of Ophthalmology at Thomas Jefferson University and member of the retina service at Wills Eye Hospital.
- Currently manages ~2500 patients with wet age-related macular degeneration.
- Involved as a clinical investigator in several collaborative trials and studies on various conditions including age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, inherited retinal degenerations and pediatric retinal disorders.
Considering the subgroup analyses from the Phase 2 DAVIO 2 trial, how do you assess the clinical profile and durability of EYP-1901 in treating wet AMD, especially in comparison to aflibercept?
Added By: catalin_adminWhat are the implications of EYP-1901 demonstrating numerical superiority in best corrected visual acuity (BCVA) and anatomic stability in patients supplement-free up to 6 months?
Added By: catalin_adminHow does EYP-1901 perform across different wet AMD patient types, considering variations in baseline BCVA, duration of diagnosis, and historical treatment burden?
Added By: catalin_adminBased on the interim data from the Phase 2 PRISM trial, how would you evaluate the safety and clinical activity of 4D-150 in patients with severe wet AMD and high treatment burden?
Added By: catalin_adminHow does 4D-150 compare to standard anti-VEGF therapies in terms of treatment burden reduction and maintaining visual acuity and retinal anatomy?
Added By: catalin_adminWith some patients being injection-free for up to 24 weeks, what are the potential long-term benefits and challenges of using 4D-150 as a one-time intravitreal injection for wet AMD?
Added By: catalin_adminWhat are the anticipated next steps in the clinical development of EYP-1901 and 4D-150, particularly regarding their upcoming Phase 3 trials?
Added By: catalin_adminGiven the results of EYP-1901 and 4D-150, how might these therapies transform the current treatment landscape and patient experience in wet AMD?
Added By: catalin_adminAre You Interested In These Questions?
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