Expert Interview
Unveiling the Potential of AFM24 in EGFR-Wildtype Non-Small Cell Lung Cancer: Insights from the AFM24-102 Phase 1/2a Study
Ticker(s): AFMDAn oncologist or lung cancer specialist with expertise in NSCLC and experience in clinical trials. The expert should have a deep understanding of NSCLC treatment, especially in the context of EGFR-wildtype cases, and be familiar with the latest advancements in immunotherapy and targeted treatments.
AFM24 is described as a tetravalent, bispecific innate cell engager (ICE). Could you elaborate on how its unique mechanism of action contributes to its efficacy in treating EGFR-wildtype NSCLC?
Added By: slingshot_insightsWith the AFM24-102 study showing 1 complete response and 2 partial responses in the EGFRwt NSCLC cohort, what does this indicate about the potential of AFM24 in treating heavily pre-treated NSCLC patients?"
Added By: slingshot_insightsConsidering that all patients in the study progressed on PD-[L]1 targeted therapy, how does AFM24's performance compare with these prior treatments in terms of efficacy and safety?
Added By: slingshot_insightsWhat are the criteria for selecting patients for AFM24 treatment in NSCLC, and how does EGFR-wildtype status influence these decisions?
Added By: slingshot_insightsAFM24 is being evaluated in combination with atezolizumab. What is the rationale behind this combination, and what synergistic effects might it have?
Added By: slingshot_insightsDr. Andreas Harstrick mentioned a significant unmet need for patients who have exhausted all previous lines of therapy. How does AFM24 aim to fulfill this need?
Added By: slingshot_insightsWith plans to expand the study to 40 EGFRwt NSCLC patients, what are the expected outcomes, and how might this influence the future direction of AFM24's clinical development?
Added By: slingshot_insightsBased on the current data, what can be inferred about the long-term safety and tolerability of AFM24 for NSCLC patients, and what are the key factors to monitor in ongoing and future studies?
Added By: slingshot_insightsAre You Interested In These Questions?
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