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Expert Interview

Slingshot members are talking to an expert! The topic is:

Discussing the potential of Amgen's KRAS-G12C- inhibitor, sotorasib, in KRAS G12C-mutated mCRC and the results from the CodeBreak 300 phase III study presented at the 2023 ESMO conference.

Ticker(s): AMGN

Who's the expert?

Institution: BC Cancer Agency

  • Medical Oncologist  at the Jack Ady Cancer Program  and Associate Clinical Professor of Medicine at the University of Calgary
  • Clinical practice includes the full spectrum of solid tumors as well as backup in malignant hematology
  • Research interests are team focused and include cost effective diagnostic testing, optimum cancer care follow-up and all aspects of community oncology practice

Interview Questions
Q1.

Could you briefly introduce yourself, your expertise, and describe your current practice setting?

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Q2.

Can you please give an overview of how you manage metastatic colorectal cancer patients and your thoughts on the CodeBreaK 300 trial data presented at ESMO 2023?

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Q3.

How many metastatic colorectal cancer patients do you manage monthly?

  • What are the current guidelines and processes for colon cancer screening?

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Q4.

Do you use assays like Shield or Cologuard for screening, and what's your experience with them?

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Q5.

What's your opinion on the effectiveness of general cancer screening tests?

  • Could you comment on the estimated annual cases of colorectal cancer in the U.S.?

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Q6.

In your experience, what percentage of metastatic colorectal cancer patients have KRAS mutations?

  • Is the KRAS G12C mutation prevalence in metastatic colon cancer patients around 3-4% accurate?

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