Expert Interview
Discussing Recent Clinical Data on Jazz Pharmaceuticals' Xywav and Avadel's LUMRYZ (sodium oxybate) for the Treatment of Narcolepsy
Ticker(s): JAZZ, AVDLInstitution: Beth Israel Deaconess Medical Center
- Associate professor of medicine at Harvard medical school, and director of the sleep center at Beth Israel Deaconess Medical Center.
- Currently manages over 60 patients with narcolepsy.
- Clinical and research interests include wearable devices, brain health in sleep disorders, hypersomnias, and complex sleep breathing and circadian syndromes.
What did you think about the primary findings of the TENOR study regarding the reasons patients utilized a Xywav individualized dosing regimen?
Added By: slingshot_insightsHow does the sodium content in Xywav compare to that in Xyrem in terms of the American Heart Association's daily ideal sodium intake for most adults?
Added By: slingshot_insightsCan you please comment on the baseline mean systolic blood pressure measurements for patients with narcolepsy and idiopathic hypersomnia in the exploratory, post-hoc analysis from two Phase 3 trials of Xywav?
Added By: slingshot_insightsHow does the sodium burden reduction from low-sodium therapies like Xywav impact the health risks in patients with sleep disorders?
Added By: slingshot_insightsCan you comment on the percentage of patients in the TENOR study reported benefiting from individualized dosing, and the most common reasons cited for taking a higher first dose?
Added By: slingshot_insightsHow does LUMRYZ differ from other sodium oxybate treatments in terms of dosing frequency?
Added By: slingshot_insightsWhat percentage of patients with narcolepsy experience poor, fragmented sleep, as mentioned in the data?
Added By: slingshot_insightsWhat's your impression on the key findings from the post-hoc analyses of the REST-ON trial regarding the improvement in EDS as measured by the Epworth Sleepiness Scale?
Added By: slingshot_insightsHow does the once-at-bedtime formulation of LUMRYZ impact the need for middle-of-the-night oxybate doses?
Added By: slingshot_insightsWhat insights did the RESTORE study provide regarding the long-term tolerability and symptom improvement with LUMRYZ in real-world use?
Added By: slingshot_insightsHow does the sodium content in LUMRYZ compare to other treatments in terms of its impact on cardiovascular health?
Can you comment on the primary outcomes of the REST-ON clinical trial that supported the FDA approval of LUMRYZ?
Added By: slingshot_insightsAre You Interested In These Questions?
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