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Edison will be hosting a call to discuss the delivery challenges and potential solutions to administering CAR-T therapies more widely upon eventual FDA approvals.Ticker(s): JUNO, KITE, CELG, NVS
Name: Dr Rafael Bejar - MD/ PhD
Institution: UCSD Moores Cancer Center
- Board certified internal medicine, oncology, and hematology, Dr. Bejar specializes in the care of patients with myelodysplastic syndromes (MDS) and related blood disorders.
- Established a MDS Center of Excellence at UC San Diego Health focused on providing the best diagnostic tools, supportive care, clinical trials, and medical expertise in one center. Currently sees ~8 patients a week with MDS as well as inpatient obligations.
- Previously worked in the community hospital setting as an internal medicine resident (Faulkner Hospital in Boston), Dr. Bejar is able to speak about the challenges of CAR-T cell administration in that setting.
This expert call is sponsored by Edison, a global advisory and independent research company. Edison's world renowned equity research platform provides deep multi-sector knowledge and an extensive network of investors, advisors and companies providing clients with a differentiated approach to advisory services. This enables Edison to truly understand its clients’ businesses and their needs and to engage more fully with stakeholders on their behalf and in a more targeted way.
CALL LEADER: Maxim Jacobs, Director of Healthcare Research, North America
Maxim joined Edison in 2015 from Guidepoint Global, where he was a Director of Survey and Tracker Research, conducting extensive primary research across healthcare markets. He also brings more than 15 years’ experience in equities to the healthcare team previously holding positions at Ridgemark Capital, Broadfin Capital, and Mehta Partners.
Please describe your background for us, including the types of facilities you see patients and your experience /knowledge of CAR-T therapies in development.Added By: joe_mccann
When looking at the current CAR-T therapies in development, please walk us through the high level challenges you would see arising in treating patients at your facility.Added By: joe_mccann
How many specialists do you think would be required at a minimum to monitor a patient undergoing treatment? How much of a challenge would this be in most hospital settings?Added By: joe_mccann
From a logistical perspective, what % of patients in the US would have a difficult time receiving therapy? Please discuss this from the point of view of traveling for check-ups, number of facilities that can actually offer treatment and any other considerations you think we should have in mind.Added By: joe_mccann
Timing of therapy: In the trials you've been involved in, what is the typical amount of time it takes from when a patient undergoes the leukapheresis until they are infused with the reprogrammed T cells?Added By: mbritz
One of the common side effects that we hear about in CAR T trials is neurotoxicity. Can you tell us about your experience in how neurotoxicity presents itself in these patients. Do you this the neurotoxicity will be common to all CAR T therapies or do you think it is specific to the target?Added By: mbritz
Pretreatment - Do you think pretreatment with cyclophosphamid/fludarabine is or will be required for all CAR T therapies? How does this pretreatment affect the challenge of delivery of CAR T therapies - is it a minor inconvenience or a major problem?Added By: mbritz
What are some of the challenges that will need to be faced as CAR T moves from targeting blood cancers to solid tumors? Do you think CAR T shows promise for treatment of solid tumors?Added By: mbritz
Can you compare and contrast the manufacturing and delivery issues of allogeneic CAR-T therapies vs autologous CAR-T therapies and your view on the impact to auto-CAR's in allo-CAR's turn out to be successful in the clinic?Added By: bioinv
What is the advantages and disadvantages of CAR-T therapy versus Dendritic Cell vaccine?Added By: lancasterca
What is an estimated cost for CAR-T therapy? Would it be priced differently for different approved indications (i.e. DLBCL vs. ALL)? Do you think it will be used as a bridge therapy to transplants?Added By: user40993375
Currently CAR T therapies are administered in the hospital setting (often in large cancer centers in major metropolitan centers. Can you envision a scenario where apheresis collections or treatments could take place in smaller regional hospitals or perhaps blood centers?Added By: mflo
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