How many patients with Major Depressive Disorder (MMD) do you have under your care?

Are you familiar with Auvelity (dextromethorphan HBr-bupropion HCl) and data to date?

Are you familiar with Caplyta (lumateperone) and data to date?

How would you best describe your practice?

What is your general view of Auvelity? What role, if any, do you see Auvelity playing in your practice? Please be specific.

How much more difficult, if any, is it for you to prescribe Auvelity than Trintellix (i.e., the hoops that a patient has to jump through and the work you have to do to meet prior auth requirements and get through insurance)? Please explain.

Do you expect the level of difficulty you face in prescribing Auvelity vs. Trintellix to improve significantly over the next 3-6 months?

Why is that? Please be specific.

How many MDD patients do you currently have on the following drugs:

• Trintellix
• Auvelity
• Buproprion

How many new MDD patients enter your practice over the course of a year?

And of those new MDD patients, how many would you expect to try Auvelity (either immediately or after failing on another drug)?

How many of your MDD patients are adequately controlled with their current drug regimen vs. inadequately controlled?

• Adequately controlled
• Inadequately controlled

Of the [X] patients that are inadequately controlled, how many of these patients do you expect to try Auvelity on?

How many patients did you start on Auvelity over the past 3 months?

Of those new Auvelity starts, what percent (%) do you expect to stay on Auvelity for at least 6 months?

Of the patients who initially respond well to Auvelity and stay on it past the first few months, what do you expect will be the total amount of time in months, on average, that they will end up staying on the drug?

How many patients total do you expect to have on Auvelity at the following points in time:

• 12/31/2023 (~6 months from now)
• 6/30/2024 (~1 year from now)
• 6/30/2025 (~2 years from now)
• 6/30/2026 (~3 years from now)

What is your general view of Caplyta? What role, if any, do you see Caplyta playing in your practice? Please be specific.

How many patients did you start on Caplyta over the past 3 months?

How many patients discontinued Capltya over the past 3 months?

How many patients do you have on Caplyta today?

How many patients total do you expect to have on Caplyta at the following points in time:

• 12/31/2023 (~6 months from now)
• 6/30/2024 (~1 year from now)
• 6/30/2025 (~2 years from now)
• 6/30/2026 (~3 years from now)