Expert Interview
A Second View: A discussion of acoramidis and part B of the ATTRibute trial in ATTR-CM (Transthyretin Amyloid Cardiomyopathy)
Ticker(s): BBIO, PFE, ALNYInstitution: Stanford
- Cardiologist and Instructor at Stanford University School of Medicine.
- Manages patients at the amyloid center at Stanford and directs the amyloid clinic at the Palo Alto VA.
- Research focuses on Investigating the molecular mechanisms behind genetic risk factors for human cardiovascular disease focusing on amyloidosis, cardio-oncology, and atherosclerotic diseases.
why do you think Part A of ATTRibute failed?
Added By: wilson_adminWhat do you think of the Part B probability of success?
Added By: wilson_adminHow do you view acoramidis compared to other options
Added By: wilson_adminThinking of the three entrants into the CM arena - vutrisiran, eplontersen, and acoramidis, characterize what you believe are the differentiating advantages/disadvantages of each?
Added By: wilson_adminDescribe how you see the marketing shaking out with the emergence of three different players with three different solutions (vutrisiran, eplontersen, and acoramidis) in the aTTR-CM market? Are there unique patient types for each?
What do you think the win ratio will be for ATTRibute-CM?
Added By: user718eef9cIn ATTR-ACT, the greatest benefit seemed to be in NYHA 1-2 irrespective of wt or m — that suggests that earlier disease responds better. Since the hypothesis is that ATTRibute-CM has a left-shifted population, should we expect a higher win ratio with AG10?
Added By: user718eef9cAre You Interested In These Questions?
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