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Expert Interview

Slingshot members are talking to an expert! The topic is:

An overview of the hereditary angioedema (HAE) treatment landscape with a focus on new therapies in development by Kalvista, Astria, and Pharvaris

Ticker(s): PHVS, KALV, ATXS

Who's the expert?

Institution:  Children's Hospital Colorado

  • Assistant Professor at the University of Colorado School of Medicine and Fellowship Director of Allergy and Immunology.
  • Treats 12 patients with HAE, over 50 patients with spontaneous urticaria and 150 total patients with EoE.
  • Clinical interests include food allergy, eosinophilic esophagitis, asthma, allergic rhinitis, eczema, drug allergy and urticaria. 

Interview Questions
Q1.

A hematologist with experience in treating hereditary angioedema.

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Q2.

Could you please you explain the mechanism of action of PHVS416 and how it differs from other treatments for hereditary angioedema?

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Q3.

What are the primary endpoints of the ongoing clinical trials for PHVS416?

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Q4.

How do the early-stage clinical trial results of PHVS416 compare to other drugs currently available for hereditary angioedema?

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Q5.

How does PHVS416 fit into the current treatment landscape for hereditary angioedema?

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Q6.

Can you discuss any potential advantages of PHVS416 over current treatments for hereditary angioedema?

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Q7.

What do you think are the biggest challenges facing PHVS416 as it moves through clinical trials?

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Q8.

What is your overall impression of PHVS416 and its potential to be a successful treatment for hereditary angioedema?

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Q9.

What do you think are the biggest potential barriers to adoption of PHVS416 in the market?

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Q10.

Can you discuss any potential side effects of PHVS416 and how they compare to side effects of current treatments for hereditary angioedema?

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Q11.

What are your thoughts on the potential pricing and reimbursement of PHVS416 in the market?

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