Expert Interview
Discussing the phase 2 SEQUOIA trial data on Arrowhead 's fazirsiran in treating A1AT liver disease
Ticker(s): ARWRInstitution: Dignity Health - St. Joseph's Hospital and Medical Center
- Chief of Hepatology and Medical Director of Liver Transplant at St. Joseph's Hospital & Medical Center in Phoenix, Arizona.
- Currently manages ~2000 patients with liver disease, 15-20 patients with A1AT liver disease, 40 with PBC
- Research interests involve nonalcoholic steatohepatitis, cirrhosis, primary biliary cholangitis, primary sclerosing cholangitis, and liver transplant.
Can you give an overview of your practice?
Added By: max_adminCan you give me an idea how many A1AD liver disease patients end up needing a liver transplant, and how long that usually takes?
Added By: max_adminOn a high level, can you discuss the approaches from Arrowhead and Vertex, siRNAs vs correctors?
Added By: max_adminHow do you think patients on existing augmentation therapy would affect efficacy, if at all?
Added By: max_adminDo you expect any variance in efficacy depending on fibrosis stage?
Added By: max_adminGiven that there are no approved therapies for the A1AD liver disease, what do you envision would be an appropriate phase 3 design, including primary endpoint?
Added By: max_adminLet’s assume fazirsiran is the 1st drug approved in AATD, either lung or liver, how do you imagine it being used vs the current SoC?
Added By: max_adminHow would you rate your enthusiasm about fazirsiran on a scale of 1-10, and you can you elaborate on why?
Added By: max_adminAre there any other approaches to A1AD, whether liver or lung disease, that you find interesting and are following?
Added By: max_adminAre there any opinions on gene therapy for A1ATD?
Added By: userfeb5f22bAre You Interested In These Questions?
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