Expert Interview
A Second Look: Comparing 89bio's pegozafermin to Akero's efruxifermin in NASH
Ticker(s): ETNB, AKROInstitution: Imperial College London
- Clinical Research Fellow and Hepatologist at Imperial College London
- Current research interest are screening pathways for NAFLD in high risk group patients
- Sub-investor for several NAFLD and HBV trials
pegozafermin vs. efruxifermin
Added By: wilson_adminHow do you think the NASH resolution data compares to efruxifermin?
Why do you think efruxifermin has a greater NASH resolution compared to pegozafermin?
Do you believe that weight loss is attributed to differences in the compound, as in the structure, and the PK profile, or to differences in patient baseline?
Pegozafermin had a lower GI toxicity compared to efruxifermin, but efruxifermin's GI toxicity was described as transient and resolving. Do you think there is a difference in the GI toxicity?
Added By: catalin_adminI noticed that efruxifermin had three times higher NASH resolution compared to fibrosis improvement than pegozafermin. Should NASH resolution be much higher than fibrosis improvement?
The placebo response for pegozafermin was lower for fibrosis than the placebo response for efruxifermin. How would you distinguish using one over the other?
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