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Expert Interview

Slingshot members are talking to an expert! The topic is:

Discussing Gilead’s Trodelvy for the treatment of HR+/HER2- Metastatic Breast Cancer, Following EMA Approval; PDUFA due February

Ticker(s): GILD

Who's the expert?

An oncologist with experience in treating HR+/HER2- Metastatic Breast Cancer.

Interview Questions
Q1.

Please describe your practice as a clinician,how many patients with   HR+/HER2- Metastatic Breast Cancer do you see on a yearly basis? Can you describe the standard of care, and take us through the most promising upcoming treatments?

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Q2.

How much of an unmet need is there for HR+/HER2- Metastatic Breast Cancer? How competitive and effective is Endocrine therapy or Chemotherapy?

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Q3.

Could you walk us through the details regarding Trodelvy’s mechanism of action and composition, and how that translate into beneficial patient outcomes:- Monoclonal antibody: The humanized monoclonal antibody, hRS7 IgG1κ, that binds to Trop-2, a transmembrane calcium signal transducer that is overexpressed in many epithelial cancers, including triple-negative breast cancer (TNBC)- Cytotoxic drug: The camptothecin-derived agent, SN-38, a topoisomerase I inhibitor act by interfering with the replicative capacity of cancer cells.-Linker: A hydrolyzable linker, with a short PEGylated unit.

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Q4.

How do Trodelvy, Trastuzumab emtansine (Kadcyla) and Trastuzumab deruxtecan (Enhertu) compare to eachother?

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Q5.

How likely would you be to use Trodelvy, judging by the clinical trial results to date?

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