Expert Interview
A Second View: A discussion of KIT inhibitors in GIST, including ripretinib (Qinlock)
Ticker(s): DCPHInstitution: MSKCC
- Associate member in the Human Oncology and Pathogenesis Program and an associate attending physician at MSKCC, and associate professor of medicine at Weill Cornell
- Laboratory research focuses on understanding the genetic and epigenetic mechanisms of transcription activation of novel oncogenic transcripts and oncogenic transcription factors in solid tumor malignancies
- Clinical practice focuses on melanoma, GIST and sarcomas
Why did Qinlock fail in all patients, and may it actually be effective in the subset of KIT Exon 11, and 17 18 mutants?
If Theseus runs a second line trial, beats Sunitinib, and its safety is okay, would 100% of your patients then go on that second line, or would there still be some Sunitinib patients?
Added By: wilson_adminWhat is your opinion regarding Exon nine? It was really striking where Sunitinib did 14 months, and Ripretinib only did 5.5 months on Exon nine.
Is it likely to be repeated when they were on that pivotal phase three study, again for Sunitinib with the selected patients?
Do you have any views on the supportive data of either of THE-630(pan-KIT) or Bezuclastinib(combination with Sunitinib) approaches, and do you think one is more likely than the other?
The company has mentioned second line against Sunitinib, just like Deciphera did. So what do you think this trial probability would be, given that molecule's differentiated platform? You think it would be more likely to be like Deciphera, or more likely that it could have some differentiated PFS?
What is your opinion about Bezuclastinib, to be able to inhibit seven eight, and just combine it with Sunitinib, so you have the same pan-KIT in two molecules?
Would efficacy determine which one you would use, or safety, since that you could avoid Sunitinib with equal, say, if they're equally efficacious, but more safe, would you use THE-630, or if efficacy was better with a Sunitinib Bezuclastinib combo, would that trump the safety advantage?
Do you know of other molecules in the second line GIST that are there already, or will be there soon that are promising?
Does NB003 look as good, or better than THE-630?
Could an ORR of 20%, and some duration, six months get THE-630 approved in a single arm? Were those the right numbers, or the right benchmark that they would need?
Are You Interested In These Questions?
Slingshot Insights Explained
Expert research benefits investors by giving them timely access to unbiased real world perspectives on highly specialized topics. Slingshot Insights' crowdfunded model makes this access available at a fraction of the cost of other expert networks.
Reason
*Slingshot Insights provides access to information, not investment advice. We work to support you and facilitate access to experts; however we are not responsible for monitoring calls for the disclosure of MNPI. You should obtain financial, legal and tax advice from your qualified and licensed advisers before deciding to invest in any security.
