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Expert Interview

Slingshot members are talking to an expert! The topic is:

Discussing 89bio’s pegozafermin in severe hypertriglyceridemia, following Phase 2 Data Results

Ticker(s): ETNB

Who's the expert?

Institution: Utah Lipid Center

  • President and Director of the Utah Lipid Center and past president of the American Board of Clinical Lipidology.
  • Treats 50 patients with hypertriglyceridemia (SHTG)
  • Responsible for writing guidelines for the American Heart Association and the American Association of Clinical Endocrinology; has co-authored over over 160 scientific articles, reviews, book chapters.

Interview Questions

Please describe your clinical practice. How many patients with SHTG do you see on a yearly basis? Could you talk to us about the standard of care?

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How well do patients respond to treatment with fenofibrate and omega-3 fatty acid therapy or Epanova, and how does it stand up to new and emerging treatment options? How critical is the need for new drugs?

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Can you talk to us about the mechanism of action of glycoPEGylated analogs of fibroblast growth factor 21 (FGF21) ? What are the benefits specific to pegozafermin, how important is the extended half-life ?

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How often do patients develop pancreatitis? What approach works best to prevent that from happening?

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Could you please share your thoughts on the Phase 2 results, where 88% of treated patients vs. 0% of placebo patients achieved a ≥30% reduction in liver fat from baseline and 24% of treated patients vs. 0% of placebo patients achieved normalized levels of liver fat at week.

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Please discuss the findings showing non-HDL-C reductions in both apo-B subtypes, apoB48 and apoB100; can you comment on pegozafermin reducing atherogenic lipoproteins and chylomicrons?

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How likely would you be to switch patients to pegozafermin?

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