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Expert Interview

Slingshot members are talking to an expert! The topic is:

A look into the IPF treatment landscape and emerging developmental therapeutics such as PLN-74809

Ticker(s): PLRX

Who's the expert?

Institution: National Jewish Health

  • Associate Professor of Pulmonary Sciences & Director of Interstitial Lung Disease program at National Jewish Health
  • Manages 80 patients with IPF.
  • Research focuses on  Interstitial Lung Diseases and specifically on those related to autoimmune diseases.

Interview Questions
Q1.

Can you describe the unmet need in IPF?

Added By: mattgamber
Q2.

What are your feelings on the safety of PLN-74809 thus far, especially given the history of the Biogen program in TGFb? What would you need to see to be confident in the safety of this program?

Added By: mattgamber
Q3.

How should we interpret the biomarker data in health volunteers so far? Do you feel this would translate directly to IPF patients?

Added By: mattgamber
Q4.

In healthy volunteers what did you make of the spike in inflammation at the 24 hour mark? The company believes this was due to the BAL procedure is that realistic to believe?

Added By: mattgamber
Q5.

What do you make of the company initiating a new Phase 2a trial at a higher dose with a longer duration? Do you think this reflects on the clean safety profile so far or possibly that lower doses and durations are not showing an impact yet?

Added By: mattgamber
Q6.

Other integrin programs in IPF have stopped development like the AbbVie's program. How confident are you that AvB6/AvB1 is the right target in IPF?

Added By: mattgamber
Q7.

The company uses pSMAD2/Smad2 as a biomarker - how reliable is this biomarker for predicting inflammation changes via TGFb?

Added By: mattgamber
Q8.

If pSMAD2/Smad2 directly translates to Collagen I why do you think the market is skeptical of this working?

Added By: mattgamber
Q9.

What would a branded agent need to show to get uptake in a now generic IPF landscape? Would you anticipate the use of combination therapy?

Added By: mattgamber
Q10.

On a scale of 1-10 how excited are you for this agent?

Added By: mattgamber
Q11.

Are there any other therapies in the clinic you are interested in? I saw Trevi Therapeutics had some recent data in IPF Cough. Is a cough only therapeutic beneficial to patients?

Added By: mattgamber

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