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Expert Interview

Slingshot members are talking to an expert! The topic is:

A look into the current and developing S1P1 modulators as treatment for Ulcerative Colitis

Ticker(s): PFE, BMY, CNTB, VTYX

Who's the expert?

Institution:  Swedish Medical Center

  • Co-director of the Inflammatory Bowel Disease Center at Swedish Medical Center, Member of the Crohn’s and Colitis Foundation of America and served as the Chair of the Medical Affairs Committee for the Pacific Northwest Chapter, Clinical Associate Professor of Medicine at the University of Washington, and IBD Lead for the Providence Physician Enterprise Puget Sound.
  • Provides multidisciplinary and integrated care for patients with inflammatory bowel diseases such as Crohn's disease and ulcerative colitis and has authored over 50 peer-reviewed articles and engaged in over 40 clinical trials.
  • Principal research interests include the use of novel technologies in the diagnosis of IBD, colorectal cancer and IBD, IBD therapy and outcomes, small bowel endoscopy and gastrointestinal bleeding.

Interview Questions

Can you please detail your clinical experience and your current practice?

Added By: sara_admin

Could you please walk us through the ulcerative colitis treatment landscape, specifically with the JAKs and the S1Ps, how often you're using them, the insurance steps required to use them, and how your patients are doing on either of those classes?

Added By: sara_admin

What did you think about the general ozanimod data package?

Added By: sara_admin

Is etrasimod going to have some better safety, or do you find this will just be almost like a "me too" agent to ozanimod?

Added By: sara_admin

Is the S1P heart rate effect a big issue in clinical practice, or is it pretty much a non-issue as you do the monitoring?

Added By: sara_admin

If an S1P could win a Crohn's disease trial, is that more valuable than a UC indication?

Added By: sara_admin

Is there going to be a way to differentiate between the different S1Ps which are aprroved/being developed?

Added By: sara_admin

There's a lot of mechanisms being pursued in UC. Is there any mechanism that's really exciting to you? Is there a possibility that the S1P class has basically leapfrogged that by the time it starts to get a little uptake, something newer in the market just snaps a lot of that first line use, whether it's an oral ENTYVIO or something similar?

Added By: sara_admin

What's your general level of acceptance for the S1P class on a scale of one to 10?

Added By: sara_admin

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