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Expert Interview

Slingshot members are talking to an expert! The topic is:

Discussing Corcept’s Lead Drug Candidate, Relacorilant + Nab-paclitaxel in recurrent, platinum-resistant ovarian cancer, following new survival data update

Ticker(s): CORT, IMGN

Who's the expert?

An oncologist with experience in treating platinum-resistant ovarian cancer.

Interview Questions
Q1.

Please describe your clinical practice. How many patients with ovarian cancer do you see on a yearly basis? What percent of ovarian cancers become platinum-resistant and how do you measure benefit when proceeding with treatment?

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Q2.

Could you please tell us more about the mechanisms of platinum resistance, and the treatment options patients with PROC have?

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Q3.

How successful have monoclonal antibodies such as bevacizumab, (which blocks blood-vessel formation by inhibiting vascular endothelial growth factor VEGF) been, in treating PROC?

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Q4.

Are drugs that target the cell cycle in platinum-resistant disease more encouraging, such as blocking the cell-cycle control protein ATR and/or Wee1 (adavosertib)?

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Q5.

How often is toxicity a major problem in patients who have already gone through many rounds of therapy, and how do you manage that?

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Q6.

Corcept reported a 33% reduction in risk of death for Relacorilant + nab-paclitaxel compared to women treated with nab-paclitaxel alone. Median OS was 13.9 months, compared to 12.2 months for women receiving nab-paclitaxel monotherapy. Could you please discuss these results, and what it means for you?

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Q7.

Can you touch briefly on the recently reported mirvetuximab soravtansine Phase 3 data from ImmunoGen?

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Q8.

Do you think Relacorilant has the potential to supplant or adjuvate other combination molecules in PROC? How likely are you to use it in the future, if approved?

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