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Expert Interview

Slingshot members are talking to an expert! The topic is:

Digging into Axsome's AXS-07 for the acute treatment of migraine

Ticker(s): AXSM

Who's the expert?

Institution: Veteran's Administration & Avidity Biosciences

  • Neurologist who treats 180-200 migraine patients over a 6 month period.
  • Fellowship trained at UCLA in movement disorders
  • While at Penn State University, founded a laboratory studying neurodegeneration and currently working in clinical development for Avidity.

Interview Questions

Roughly how many patients with migraine do you currently manage?

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On a scale from 1-10 (10 being extremely excited) where would you rate your level of excitement for AXX-07?

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Please describe the treatment algorithm that you utilize 

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Has your triptan usage up front been impacted at all by availability of oral CGRP's, or are triptans still preferred predominantly first line 

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Overall view of clinical data on AXS07 in terms of safety and efficacy

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Do you currently prescribe triptans with meloxicam or other NSAIDS as an option for patients not sufficiently helped by triptans?

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Does AXS07 data encourage you to use NSAID + triptan more often?  

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Does AXS07 have a market opportunity when generic components of the combo are available separately very cheaply?

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Sparing of need for rescue medications shown in INTERCEPT trial with AXS07 - Is this a meaningful result? 

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Is formulation of AXS07 with both components together (and MOSEIC meloxicam) leading to more rapid onset of benefit something you consider credible? Or not likely?

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Is there a pricing tier that Axsome could set for AXS07 where although it's more expensive than the generic components separately, they could create an opportunity for the drug by coming in significantly lower than where Treximet was priced?

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Is AXS07 an analogous situation to Treximet?   
Did you ever use Treximet at all?

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