Expert Interview
Discussing Welireg (Belzutifan) as a treatment in patients with von Hippel-Lindau (VHL) disease with associated renal cell carcinoma
Ticker(s): MRKInstitution: MD Anderson
- Professor Genitourinary Medical Oncology at The University of Texas MD Anderson Cancer Center & Director of VHL Clinical Center.
- Involved in tissue-based translational research in renal cell carcinoma and VHL disease; Heads a number of investigator-initiated clinical trials and is the PI of the Department of Defense Kidney Cancer Research Consortium.
- Current work focuses on understanding the drivers of renal cell carcinoma tumor ontogeny and the development of informative models of tumor-microenvironmental interaction.
Please describe your clinical practice. Roughly how many patients with VHL do you currently manage?
Added By: sara_adminWhat are your thoughts on the use of Welireg and how does it compare to other treatment options?
Added By: sara_adminOn a scale from 1-10 (10 being extremely excited), how would you rate your level of excitement for Welireg?
Added By: sara_adminCan you discuss the role of HIF2 alpha in oncogenesis and which tumors in particular this plays a significant role?
Who are the specific types of patients you are treating so far with Welireg?
Any off label use in advanced RCC?
What is Welireg's potential in more broad application beyond VHL for RCC or other tumor types?
Can you discuss the unmet need in RCC?
Did you consider the trial data for label indication compelling?
Can you address the toxicity profile and whether you think it has potential in combinations?
Related to the checkpoint inhibitor combination, what are your thoughts on HIF mechanism and how it impacts immune cell populations?
What are your Clinical observations post-approval? Are you seeing responses? Any responses in advanced RCC off label usage?
What is your view of Welireg's future/potential in RCC - 2nd line immunotherapy potential? Combos?
Long time to response in trial data - How does this manifest itself? Are responders experiencing stable disease over that period? Are you able to discern likely responders earlier?
How has the process been for getting patients approved for access to Welireg?
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