Expert Interview
A Second Opinion: Discussing Tepezza's launch and remaining unmet medical need in treating Thyroid Eye Disease (TED)
Ticker(s): HZNP, VRDN, ValenzaBio, VasaraGenInstitution: California Oculoplastics
- Sees 2-3 patients with TED per week and manages at least 50.
- Involved in multiple TED trials in his career including: ASCEND GO-2: Study of batoclimab (RVT-1401), Phase 2/3 clinical trials for Tepezza, and work on IGF-1R pathways.
- Author of paper: Enrichment of IGF-1R and PPAR Signaling Pathways in Orbital Inflammatory Diseases: Steps Toward Understanding Pathogenesis.
Do you see chronic (inactive) TED patients or acute (active) or both?
- How do you differentiate between the two?
What are your thoughts on Tepezza?
- Efficacy? In Chronic? Acute?
- Safety? Different in chronic? Acute?
- Do you believe it will be equally effective in chronic patients?
- Thoughts on the Ph4 chronic study expected 2H22?
Efficacy details:
- Do most patients complete the full 8 infusion tx cycle?
- Have you ever had patients stop early and get full benefit?
- When do you start to see full benefit?
- Anything you wished the drug was better at in term of efficacy?
Safety
- What are your thoughts on the AE profile based on your experience?
- And safety in your experience v. label?
- Any difference in AE profile in different groups of patients?
- Elderly v. young?
- Chronic v. acute?
This is IV. Thoughts on subQ options?
- HZNP is doing subQ, too. What would a subQ option in TED mean for you? For patients?
What are your thoughts on a drug like secukinumab which is approved and well-understood inother indications?
Added By: joe_mccannThoughts on IMVT’s batoclimab?
- Showed early positive data but halted due to LDLs. Thoughts on initial efficacy?
- LDL levels concern you?
- Thoughts generally on anti-FcRns in TED?
Are you aware of any of the other players?
- Viridian has both an IV and subQ option. Thoughts?
- VasaraGen? Thoughts on an oral IGF-1R + insulin inhibitor option?
From member: If you can have the host ask what attributes for a next-generation TED IGFR drug would be ideal, can Tepezza/the space be improved upon? Injectable? Shorter dosing regimen? Room for better efficacy or safety?
Added By: joe_mccannAre You Interested In These Questions?
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