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Expert Interview

Slingshot members are talking to an expert! The topic is:

Discussing Kymera Therapeutics’ KT-474 - IRAK4 Dermatology Program

Ticker(s): KYMR

Who's the expert?

A dermatologist with experience in treating Atopic Dermatitis and/or Hidradenitis Suppurativa 

Interview Questions

Please tell us about your clinical experience. How many patients with dermatological issues do you treat on a yearly basis, what is the typical therapy choice for Atopic Dermatitis and Hidradenitis Suppurativa?

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Can you walk us through the mechanism of action and reasoning behind targeting IRAK4, IRAKIMiD, and STAT3, centering on a single critical signaling node within the IL-1R/TLR or JAK/STAT pathways, and more specifically on IRAK-4 as a drug target in inflammation?

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Looking at the recently presented Phase 1 data, what is your impression regarding the overall efficacy and safety of KT-474?

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Considering that a deficiency in IRAK4 kinase was found to be associated with disability to recognize viral and bacterial invaders, what are the safety concerns associated with use of this therapy? How do you see the risks-benefits ratio?

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What would you attribute the modest progress in the development of potential inhibitors of IRAK4 to?

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How satisfactory is the result of 85% target degradation within the SAD portion, with IRAK4 degradation after a single oral dose lasting for at least six days at all dose levels?

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How likely is it for adverse events to appear with prolonged use, and what might they look like?

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How likely would you be to use KT-474 in your patients?

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