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Digging into the Sickle Cell landscape with competing therapies Oxbryta (voxelotor) and ADAKVEO (crizanlizumab)

Ticker(s): GBT, GLYC, NVS, BLUE, PFE

Who's the expert?

Name: Dr John Strouse - MD

Institution: Duke University

  • Associate Professor of Medicine and Pediatrics and Director of the Adult Sickle Cell Program at Duke University.
  • Currently cares for 200 patients with Sickle Cell Disease (100 children & 100 adults) and15 patients with hereditary hemochromatosis.
  • Research has focused on the epidemiology, risk factors, and prevention of the pulmonary and central nervous system complications of sickle cell disease and includes retrospective and prospective cohort studies and clinical trials; local site co-investigator on trials for GBT-440 and rivapansel.

Interview Questions
Q1.

Questions from STAT's Adam Feuerstein to come! 

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Q2.

Many of the next generation of SCD therapies focus on HbF induction. What magnitude of change in HbF do you believe is required for oral small molecule drugs to be useful and is it relative or absolute HbF change that is more important?

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Q3.

Do you believe there will be wider adoption of Adakveo over Oxybryta, or vice versa? What will be the major drivers for a clinician to prescribe one over the other?

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Q4.

Following the approvals of Adakveo and Oxbryta, what remains the unmet need for SCD patients? What gaps and opportunities remain that drugs in development could address?

Added By: bbresearch
Q5.

RE:   VOX-     whats the tolerability in real world, of 5 pills per day

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Q6.

Thoughts on gene therapies in development for SCD?

Added By: bbresearch

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