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Expert Interview

Slingshot members are talking to an expert! The topic is:

Discussing the unmet medical need and relevant endpoints in obstructive and non-obstructive Hypertrophic Cardiomyopathy (HCM)

Ticker(s): MYOK

Who's the expert?

Institution: The Permanente Medical Group (TPMG)

  • Invasive cardiologist a multi specialty group with 600 physicians. 
  • Group manages about 150-200 patients with Hypertrophic cardiomyopathy.
  • Familiar with the Mavacamten mechanism of action.

Interview Questions

Please tell us about your clinical practice, background in treating Obstructive/Nonobstructive Hypertrophic/Dilated Cardiomyopathy, and research in the space. How many patients do you treat,what is the first line of therapy? What % of patients do not respond well to first line?

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How much of a need for new treatments is still there? Which ones get prescribed often and under what specific circumstances?

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Do you emphasize treating the underlying cause, or do you focus more on alleviating symptoms? How often does the enlarged myocardium regenerate to its normal size following medication?

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What can you tell us about the recent P3 trial launch of mavacamten as an alternative to septal reduction therapy (SRT) ?

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What are the risks/ benefits associated with surgical myectomy or alcohol septal ablation procedures?

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What is Mavacamten’s mechanism of action leading to normalization of the number of myosin-actin cross-bridges?

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How important is the allosteric control of beta cardiac myosin? Was it possible prior to the development of Mavacamten?

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How likely would you be to switch your patients to Mavacamten if approved?

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How important is the fact that mavacamten can be dosed to reduce left ventricular outflow tract (LVOT) gradient below the guideline-based definition for obstruction?

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What are your views on using proBNP as an endpoint for noHCM? Are there other endpoints you think are more informative?

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