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Analysis of the Dilated/ Hypertrophic Cardiomyopathy Space- with phase II Mavacamten data expected Q4Ticker(s): MYOK
Name: Dr Roxana Ghashghaei - MD
Institution: UC Irvine
- Cardiologist at UC Irvine with a focus on cardiomyopathies.
- Currently treats 150 patients with Hypertrophic Cardiomyopathy.
- Published at the AHA and ISHLT with regards to advanced cardiomyopathies as well as mechanical circulatory support.
Please tell us about your clinical practice, background in treating Obstructive/Nonobstructive Hypertrophic/Dilated Cardiomyopathy, and research in the space. How many patients do you treat,what is the first line of therapy? What % of patients do not respond well to first line?Added By: slingshot_insights
How much of a need for new treatments is still there? Which ones get prescribed often and under what specific circumstances?Added By: slingshot_insights
Do you emphasize treating the underlying cause, or do you focus more on alleviating symptoms? How often does the enlarged myocardium regenerate to its normal size following medication?Added By: slingshot_insights
What can you tell us about the recent P3 trial launch of mavacamten as an alternative to septal reduction therapy (SRT) ?Added By: slingshot_insights
What are the risks/ benefits associated with surgical myectomy or alcohol septal ablation procedures?Added By: slingshot_insights
What is Mavacamten’s mechanism of action leading to normalization of the number of myosin-actin cross-bridges?Added By: slingshot_insights
How important is the allosteric control of beta cardiac myosin? Was it possible prior to the development of Mavacamten?Added By: slingshot_insights
How important is the fact that mavacamten can be dosed to reduce left ventricular outflow tract (LVOT) gradient below the guideline-based definition for obstruction?Added By: slingshot_insights
In the PIONEER-OLE study, Mavacamten treatment resulted in reductions in patients’ resting and provoked LVOT gradient while maintaining a left ventricular ejection fraction (LVEF) above 55% at all times of assessment during the study through week 36. How do those nrs. translate to an improvement in the patients’ outcomes?Added By: slingshot_insights
How likely would you be to switch your patients to Mavacamten if approved?Added By: slingshot_insights
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