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Expert Interview

Slingshot members are talking to an expert! The topic is:

An in-depth examination of tradipitant, following Vanda’s release of its Motion Sickness results

Ticker(s): VNDA

Who's the expert?

A neurologist with experience in Motion Sickness and knowledge of Vanda’s tradipitant.

Interview Questions
Q1.

Please tell us about your clinical experience. How many patients do you see with Motion Sickness, and what is your treatment of choice?

Added By: slingshot_insights
Q2.

What is the mechanism of action of a neurokinin-1 receptor antagonist like tradipitant?

  1.  What characteristics of it made Vanda pursue atopic dermatitis and gastroparesis indications as well?

Added By: slingshot_insights
Q3.

In the recent data, 72.2% of the placebo treated patients experienced vomiting vs 15.8% of those treated with tradipitant under "rough" conditions. However, the specific conditions and how they are controlled are unclear; is there any standardisation for this type of motion sickness trials?

  1. What is your interpretation of the data and how does it compare to rivaling treatments?

Added By: slingshot_insights
Q4.

In “Calm Sea” situations, the Worst MSSS score for patients on tradipitant was higher (3.4) than placebo (3.32). In the “Rough Sea” scenario, tradipitant scored 3.19 and placebo 4.57. What do you attribute those differences to?

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