Clinical Data
Across all three diseases under study, strong improvements in vision and retinal anatomy were observed over 12 weeks. Vision is measured as change in Best Corrected Visual Acuity (BCVA) on a standardized eye chart, and retinal anatomy is measured as change in retinal central subfield thickness (CST) using optical coherence tomography (OCT) imaging. The efficacy data presented at ASRS include outcomes from 35 patients in the study who had reached the week 12 visit. In the study, patients are being treated with three monthly doses of either 2.5 mg or 5 mg KSI-301 and followed for 7 months thereafter, with additional treatments according to protocol-specified retreatment criteria.